Hemokinin 1 (human) ( )

Catalog No. M30666 CAS No. 491851-53-7

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Product Name

Hemokinin 1 (human)
Note

Research use only, not for human use.
Brief Description

Endogenous substance P homolog that is a selective agonist at the tachykinin NK1 receptor (IC50 values are 1.8, 370 and 480 nM for NK1, NK3 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on B-cells in vitro and is antihypertensive in vivo.
Description

Endogenous substance P homolog that is a selective agonist at the tachykinin NK1 receptor (IC50 values are 1.8, 370 and 480 nM for NK1, NK3 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on B-cells in vitro and is antihypertensive in vivo.
Synonyms
Pathway

GPCR/G Protein
Target

Neurokinin Receptor
Recptor

——
Research Area

——
Indication

——

CAS Number

491851-53-7
Formula Weight

1185.4
Molecular Formula

C54H84N14O14S
Purity

>98% (HPLC)
Solubility

water:0.70 mg/mL
SMILES

[H]N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O
Chemical Name

1. Bellucci et al (2002) Pharmacological profile of the novel mammalian tachykinin hemokinin 1. Br.J.Pharmacol. 135 266 PMID:

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